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klinefelter syndrome teeth

If you or your son has been diagnosed with Klinefelter syndrome, you might find it useful to find out more about it and get in touch with others affected by it. This is called taurodontism. Klinefelter syndrome is a genetic condition affecting males, and it often isn't diagnosed until adulthood.Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. Success in that realm rarely comes without a great struggle for those with Klinefelter syndrome. Not all males who have the extra X sex chromosome suffer from this syndrome. Try our interactive tool for help finding information, services, experts, financial aid, and more! Abstract. Chromosomes are packages of genes found in every cell in the body. We want to hear from you. Do you know of a review article? If you do not want your question posted, please let us know. This chromosome carries extra copies of genes, which interfere with the development of the testicles and mean they produce less testosterone (male sex hormone) than usual. Enlarged teeth with a thinning surface is very common in Klinefelter syndrome. This can be seen on dental x-rays. Almost one-half of men with KS have taurodontism (pronounced tawr-oh-DAWNT-iz-uhm), a dental problem in which the teeth have larger-than-normal chambers for holding pulp (the soft tissue that contains nerve endings and blood vessels) and shorter-than-normal tooth roots, both of which make it easier for tooth decay to develop. Every male cell consists of 44 autosomes and XY sex chromosome. In many cases, it's only detected if a man with the condition undergoes fertility tests. But in Klinefelter syndrome, a boy is born with an extra copy of the X chromosome (XXY). Klinefelter syndrome (KS) is the most common chromosomal abnormality in humans. About 40% of patients have taurodontism, a dental finding characterized by enlargement of the molar teeth by an extension of the pulp. Klinefelter syndrome also increases the risk of: Attention deficient hyperactivity disorder (ADHD) Autoimmune disorders, such as lupus, rheumatoid arthritis, and Sjögren syndrome; Breast cancer in men; Depression To minimise the risk of type 2 diabetes, it is particularly important that a healthy diet is maintained. TRT may be considered once puberty begins and may help with the development of a deep voice, facial and body hair, an increase in muscle mass, reduction in body fat, and improvement in energy. Visit the group’s website or contact them to learn about the services they offer. Klinefelter syndrome is caused by an additional X chromosome. Symptoms in KS are highly variable. Klinefelter syndrome is not necessarily anything serious, but treatment can help reduce some of the symptoms if necessary. You can help advance Vertical enlargement of the molar pulp chamber was termed taurodontism (“bull-like” teeth) by Keith (1913). Adults with Klinefelter syndrome may also have primary hypogonadism (decreased testosterone production), small and/or undescendent testes (cryptorchidism), enlarged breast tissue (gynecomastia), tall stature, and/or inability to have biological children (infertility), as well as an abnormal opening of the penis (hypospadias), and an small penis (micropenis). You may want to review these resources with a medical professional. Klinefelter syndrome is a chromosomal condition in boys and men that can affect physical and intellectual development. Nevertheless, frequent characteristics are small testes, azoospermia and hypergonadotropic hypogonadism. Regular exercise is also likely to help. Males with poly-X Klinefelter syndrome have more than one extra X chromosome, so their symptoms might be more pronounced than in males with KS. Symptoms ... Enlarged teeth with a thinning surface is very common in Klinefelter syndrome. Conclusions: Our results confirm the higher prevalence of taurodontism in Klinefelter's patients compared to the normal population (12.5% vs. 2.0%). Do you know of an organization? Have a question? Next review due: 20 May 2022, inability to have children naturally (infertility), underactive thyroid gland (hypothyroidism), in babies and toddlers – learning to sit up, crawl, walk and talk later than usual, being quieter and more passive than usual, in childhood – shyness and low self-confidence, problems with reading, writing, spelling and paying attention, mild, in teenagers – growing taller than expected for the family (with long arms and legs), broad hips, poor muscle tone and slower than usual muscle growth, reduced facial and body hair that starts growing later than usual, a small penis and testicles, and, autoimmune disorders (where the immune system mistakenly attacks the body), such as, speech and language therapy during childhood to help with speech development, educational and behavioural support at school to help with any learning difficulties or behaviour problems, psychological support for any mental health issues. They can direct you to research, resources, and services. Klinefelter syndrome is a chromosomal disorder wherein there is an extra X chromosome in the cells of the affected males. About one of every 500 males has an extra X chromosome, but many don't have any symptoms. The extra genetic information may either be carried in every cell in the body or it may only affect some cells (known as mosaic Klinefelter syndrome). Poly-KS males might also show slight differences in other physical features. Klinefelter's syndrome is named after Harry F. Klinefelter (cline-felter) who first described the syndrome in the USA in 1942. Menu ter's syndrome patients (19.4%), while it wasseen in 2.1% of the control males and 4.8% of the control females, indicating a significantly higher ratio in the Klinefelter's syndrome group (Table 1). Klinefelter syndrome, also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males. We remove all identifying information when posting a question to protect your privacy. Klinefelter syndrome does not usually cause any obvious symptoms early in childhood, and even the later symptoms may be difficult to spot. Boys and men with Klinefelter syndrome are still genetically male and often will not realize they have this extra X chromosome (47, XXY), but occasionally it can cause problems that may require treatment, problems such as a small penis, small testes and infertility. By now various dental features in these patients have been reported but to our knowledge this is the first report of multiple impacted teeth in the Klinefelter syndrome. Due to the wide discrepancy of incidence of taurodontism reported in literature (0.04%-48.0% in normal population; 12.5%-88.0% … Living with a genetic or rare disease can impact the daily lives of patients and families. We want to hear from you. Normally a person, whether male or female, has a total of 46 chromosomes in … Skeletal malocclusion is caused by distortion of proper mandibular and/or maxillary growth during fetal development which, if untreated, may lead to dental deformities, bruxism, teeth-crowding, trismus,… Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. This is called taurodontism and can be seen on dental x-rays. Get the latest research information from NIH: https://www.nih.gov/coronavirus (link is external). It is caused by the development of one or more copies of the X chromosome in the cells. Genetics Education Materials for School Success (GEMSS), National Human Genome Research Institute's. In childhood, they may also have seizures, crossed eyes, constipation, and recurrent ear infections. Having a more normal testosterone level can help affected people develop bigger muscles, a deeper voice, and facial and body hair, and may also increase sexual desire, enlarge the. Klinefelter syndrome’s impact on oral health is manifested in enlarged teeth with a thinning surface. Variants of Klinefelter syndrome (such as 48,XXXY, 49,XXXXY) are much rarer, occurring in 1 in 50,000 to 1 in 85,000 or fewer newborns. Often, symptoms are subtle and subjects do not realize they are affected. Previous studies on the sex chromosome Often males affected by this genetic condition experience reduced testosterone production due to the small size of testicles and penis. Infertility tends to be the main problem, although there are treatments that can help. Do you have updated information on this disease? Results: Taurodont teeth were observed in 2 of the 16 Klinefelter's patients (12.5%) and in 2 of 100 normal males (2.0%). REFERENCES 1. Lähdesmäki R(1), Alvesalo L. Author information: (1)Department of Oral Development and Orthodontics, Institute of Dentistry, University of Oulu and University Hospital of Oulu, Finland. Inclusion on this list is not an endorsement by GARD. Questions sent to GARD may be posted here if the information could be helpful to others. It primarily affects the molar teeth at the back of the mouth and was named as such because it was thought to look like a bull’s head with horns on x-ray images of teeth, hence named after Taurus the bull. There are 2 types of chromosome, called the sex chromosomes, that determine the genetic sex of a baby. This change in the egg or sperm seems to happen randomly. The results of one study on non-. Oznurhan: Treatments of Klinefelter syndrome 24 Taurodontic teeth could be a clinical sign of this syndrome and the pediatric dentist should refer for chromosome analysis. Klinefelter syndrome occurs if boys are born with an extra X chromosome. 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